APA
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Zargartalebi, H., Yousefi, H., Flynn, C. D., Gomis, S., Das, J., Young, T. L., … Kelley, S. (2022). Capillary-Assisted Molecular Pendulum Bioanalysis. Journal of the American Chemical Society.
Chicago/Turabian
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Zargartalebi, H., Hanie Yousefi, Connor D. Flynn, Surath Gomis, Jagotamoy Das, Tiana L Young, Emily A. Chien, et al. “Capillary-Assisted Molecular Pendulum Bioanalysis.” Journal of the American Chemical Society (2022).
MLA
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Zargartalebi, H., et al. “Capillary-Assisted Molecular Pendulum Bioanalysis.” Journal of the American Chemical Society, 2022.
BibTeX Click to copy
@article{h2022a,
title = {Capillary-Assisted Molecular Pendulum Bioanalysis.},
year = {2022},
journal = {Journal of the American Chemical Society},
author = {Zargartalebi, H. and Yousefi, Hanie and Flynn, Connor D. and Gomis, Surath and Das, Jagotamoy and Young, Tiana L and Chien, Emily A. and Mubareka, S. and McGeer, A. and Wang, Hansen and Sargent, E. and Nezhad, A. S. and Kelley, S.}
}
The development of robust biosensing strategies that can be easily implemented in everyday life remains a challenge for the future of modern biosensor research. While several reagentless approaches have attempted to address this challenge, they often achieve user-friendliness through sacrificing sensitivity or universality. While acceptable for certain applications, these trade-offs hinder the widespread adoption of reagentless biosensing technologies. Here, we report a novel approach to reagentless biosensing that achieves high sensitivity, rapid detection, and universality using the SARS-CoV-2 virus as a model target. Universality is achieved by using nanoscale molecular pendulums, which enables reagentless electrochemical biosensing through a variable antibody recognition element. Enhanced sensitivity and rapid detection are accomplished by incorporating the coffee-ring phenomenon into the sensing scheme, allowing for target preconcentration on a ring-shaped electrode. Using this approach, we obtained limits of detection of 1 fg/mL and 20 copies/mL for the SARS-CoV-2 nucleoproteins and viral particles, respectively. In addition, clinical sample analysis showed excellent agreement with Ct values from PCR-positive SARS-CoV-2 patients.
